Poisoning in pediatrics for suicidal purposes: report of two cases
Article Sidebar
How to Cite
This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Downloads
Societal impact
Main Article Content
Abstract
Suicide is one of the most important causes of mortality in teenagers. In 2014, pesticides were the second most frequent source for chemical poisoning in Colombia. This shows the need of addressing the topic, all the more important in the pediatric scenario. The cases presented below refer to suicide attempts related to the use of Organophosphates and Sodium Fluoroacetate (a rodenticide). The gap in the literature regarding the management of pediatric poisoning pesticides, more particularly related to Sodium Fluoroacetate, presents an opportunity for improvement in the approach and the impact on morbidity and mortality of these patients.
Article Details
References
Shain B. Suicide and suicide attempts in adolescents. Pediatrics. 2016;138:1-11.
Defunciones por grupos de edad y sexo, según departamentos de residencia y grupos de causas de defunción (Lista Colombia 105 de mortalidad). DANE información estratégica, gobierno de Colombia. Informe preliminar 2017.
República de Colombia, Instituto Nacional de Salud. Informe intoxicaciones por Sustancias Químicas, Colombia 2014.
Fernández D, Mancipe L, Fernández D. Intoxicación por organofosforados. Revista Unal. 2010;18(1):84-92.
República de Colombia, Instituto Nacional de Salud. Informe intoxicaciones por Sustancias Químicas, Colombia 2011.
Gunnell D, Eddleston M, Phillips M, Konradsen F. BMC Public Health. 2007;7:357.
Calello D, Henretig F. Pediatric toxicology: Specialized approach to the poisoned child. Emerg Med Clin North Am. 2014;32:29–52.
Mowry J, Spyker D, Brooks D, Zimmerman A, Schauben J. ClinToxicol (phila). 2016;54(10):924–1109.
Holstege C, Dobmeier S, Bechtel L. Emerg Med Clin North Am. 2008;25:715-739.
Rastogi S, Ravishanker D, Tripathi S. Study of neurologic symptoms on exposure to organophosphate pesticides in the children of agricultural workers. Indian J Occup Environ Med. 2010;14(2):54-57.
Rauh V, Garfinkel R, Perera F, Andrews H, Hoepner L, Barr D, et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics. 2006;118(6):1845-1859.
Goodman and Gilman´s the pharmacological Bases of Therapeutics. MccGraw Hill. 2011 (12):171-177.
Joynal M, Abu A, Basher A, Maude R, Hoque G, Faiz M. Open label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh. J Med Toxicol. 2012;8:108–117.
Jones P, Dauger S, Denjoy I, Pinto N, Alberti C, Boulkedid R, et al. The effect of atropine on rhythm and conduction disturbances during 322 critical care intubations. Pediatr Crit Care Med. 2013;14:289–297.
Chi CH, Lin T, Chen KW. Human and experimental toxicology. 1999;18:351-353.
Chi CH, Chen KW, Chan SH, Wu MH, Huang JJ. Clinical presentation and prognostic factors in sodium monofluoroacetate intoxication. J Toxicol Clin Toxicol. 1996;34 (6):707-712.
Hutchens JO, Wagner H, Podolsky B, McMagon T. The effect of ethanol and various metabolites on fluoroacetate poisoning. J Pharmacol Exp Ther. 1949;95:62-69.
Prasanna CV, Ramakrishnan S. Effect of acetaldehyde on carbohydrate metabolism in rat brain. Indian J Biochem Biophys. 1984;21:121-122.
Peña L, Parra S, Rodríguez C, Zuluaga A. Guía para el manejo del paciente intoxicado. Departamento de Antioquia - Dirección Seccional de Salud y Facultad de Medicina de la Universidad de Antioquia. 2009.
Granada J, Rodríguez D. Intoxicación por fluoroacetato de sodio. Rev Fac Med. 2014;62(1):137-140.
Proudfoot A, Bradberry S, Vale J. Sodium fluoroacetate poisoning. Toxicol Rev. 2006;25(4):213-219.
Collicchio-Zuanaze RC, Sakate M, Schwartz DS, Trezza E, Crocci AJ. Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: Clinical and electrocardiographic evaluation. Hum Exp Toxicol. 2006;25:175-182.
Nogué S, Corominas N, Soy D, Cino J. Emulsión lipídica intravenosa: un nuevo antidoto para uso en reanimación. Emergencias. 2011;23:378-385.
Rothschild L, Bern S, Oswald S, Weinberg G. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med. 2010;18:51-59
Huang JM, Xian H, Bacaner M. Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci USA. 1992;89(14):6452-6456.
Pfeffer C, Zuckerman S, Plutchik R, Mizruchi M. Suicidal behavior in normal school children: A comparison with child psychiatric inpatients. J Am Acad Child Psychiatry. 1984;23(4):416-423.
Cochrane-Brink KA, Lofchy JS, Sakinofsky I. Clinical rating scales in suicide risk assessment. Gen Hosp Psychiatry. 2000;22(6):445-451.