Cyanide poisoning, perspective from the emergency room: report of two cases and literature review
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Abstract
Cyanide intoxication is a rare condition. Yet, it leads to a high mortality, especially when proper treatment is not available. The exposure to this substance may occur via inhalation or oral ingestion. The basis of this intoxication´s treatment is on little case series and reports; this is due to the fact that the literature to support it remains scant and unclear. Based on physiopathological aspects, within this evidence the following are particularly relevant: sodium nitrile, amile nitrile, sodium tiosulphite, and hidroxicobalamin, as part of this intoxication´s treatment.
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Gracia R, Shepherd G. Cyanide poisoning and its treatment. Pharmacotherapy. 2004;24(10):1358- 1365.
Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th Annual Report. Clin Toxicol. 2017;55(10):1072-1254.
Walsh DW, Eckstein M. Hydrogen cyanide in fire smoke: An underappreciated threat. Emerg Med Serv. 2004;33(10):160-163.
Cyanide poisoning [Internet]. [citado 23 de enero de 2018]. Disponible en: http://cursoenarm. net/UPTODATE/contents/mobipreview.htm?13/47/14065/abstract/18
Vogel SN, Sultan TR, Ten Eyck RP. Cyanide poisoning. Clin Toxicol. 1981;18(3):367-383.
Bismuth C, Baud FJ, Djeghout H, Astier A, Aubriot D. Cyanide poisoning from propionitrile exposure. J Emerg Med. 1987;5(3):191-195.
Weger NP. Treatment of cyanide poisoning with 4-dimethylaminophenol (DMAP)--experimental and clinical overview. Fundam Appl Toxicol. 1983;3(5):387-396.
Mégarbane B, Delahaye A, Goldgran-Tolédano D, Baud FJ. Antidotal treatment of cyanide poisoning. J Chin Med Assoc. 2003;66(4):193-203.
Cummings TF. The treatment of cyanide poisoning. Occup Med Oxf Engl. 2004;54(2):82-85.
O’Brien B, Quigg C, Leong T. Severe cyanide toxicity from «vitamin supplements». Eur J Emerg Med. 2005;12(5):257-258.
Vesey CJ, Cole PV, Simpson PJ. Cyanide and thiocyanate concentrations following sodium nitroprusside infusion in man. Br J Anaesth. 1976;48(7):651-660.
Bradbury JH, Cliff J, Denton IC. Uptake of wetting method in Africa to reduce cyanide poisoning and konzo from cassava. Food Chem Toxicol Int J. 2011;49(3):539-542.
Hall AH, Saiers J, Baud F. Which cyanide antidote? Crit Rev Toxicol. 2009;39(7):541-552.
Jamal A, Phillips E, Gentzke AS, Homa DM, Babb SD, King BA, et al. Current cigarette smoking among adults - United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(2):53-59.
Iregui P. Envenenamiento por cianuro. Rev Colomb Psiquiatr. 2002;31(4):330-334.
Holstege CP, Kirk MA. Cyanide and hydrogen sulfide. En: Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, editores. Goldfrank’s Toxicologic Emergencies [Internet]. 10a ed. New York, NY: McGraw-Hill Education; 2015 [citado 18 de enero de 2018]. Disponible en: accessemergencymedicine.mhmedical.com/content.aspx?aid=1108437355
Shepherd G, Vélez LI. Role of hydroxocobalamin in acute cyanide poisoning. Ann Pharmacother. 2008;42(5):661-669.
Hall AH, Doutre WH, Ludden T, Kulig KW, Rumack BH. Nitrite/thiosulfate treated acute cyanide poisoning: Estimated kinetics after antidote. J Toxicol Clin Toxicol. 1987;25(1-2):121-133.
Baud FJ, Barriot P, Toffis V, Riou B, Vicaut E, Lecarpentier Y, et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med. 1991;325(25):1761-1766.
MacLennan L, Moiemen N. Management of cyanide toxicity in patients with burns. Burns J. 2015;41(1):18-24.
Guía Para El Manejo de Emergencias Toxicológicas [Internet]. Scribd. [citado 24 de enero de 2018]. Disponible en: https://es.scribd.com/document/358352911/Guia-Para-El-Manejo-deEmergencias-Toxicologicas
Brueske PJ. ED management of cyanide poisoning. J Emerg Nurs. 1997;23(6):569-573.
Borron SW, Baud FJ, Barriot P, Imbert M, Bismuth C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med. 2007;49(6):794-801.
Nelson L. Acute cyanide toxicity: mechanisms and manifestations. J Emerg Nurs. 2006;32(4 Suppl):S8-11.
Jang DH, Nelson LS, Hoffman RS. Hydroxocobalamin and sodium thiosulfate versus sodium nitrite and sodium thiosulfate in acute cyanide toxicity. Ann Emerg Med. 2010;55(6):582.
Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med. 1986;15(9):1067-1074.
Borron SW. Recognition and treatment of acute cyanide poisoning. J Emerg Nurs. 2006;32(4 Suppl):S12-18.
Reade MC, Davies SR, Morley PT, Dennett J, Jacobs IC, Australian resuscitation council. Review article: management of cyanide poisoning. Emerg Med Australas. 2012;24(3):225-238.
Howland MA. Antidotes in depth. En: Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, editores. Goldfrank’s Toxicologic Emergencies [Internet]. 10.a ed. New York, NY: McGrawHill Education; 2015 [citado 23 de enero de 2018]. Disponible en: accessemergencymedicine. mhmedical.com/content.aspx?aid=1108423335
Marraffa JM, Cohen V, Howland MA. Antidotes for toxicological emergencies: A practical review. Am J Health Syst Pharm. 2012;69(3):199-212.
Schapira K, Kessler BD, Howland MA, Su M. Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model. Ann Emerg Med. 2015;65(2):234-235.
Lavon O. Early administration of isosorbide dinitrate improves survival of cyanide-poisoned rabbits. Clin Toxicol. 2015;53(1):22-27.
Lavon O, Avrahami A, Eisenkraft A. Effectiveness of isosorbide dinitrate in cyanide poisoning as a function of the administration timing. BMC Pharmacol Toxicol. 2017;18(1):13.
Challenges and advances in intubation: Rapid sequence intubation. ClinicalKey [Internet]. [citado 26 de febrero de 2017]. Disponible en: https://www.clinicalkey.es/#!/content/playContent/1- s2.0-S0733862708000990?returnurl=null&referrer=null
Fármacos que actúan en la unión neuromuscular y en los ganglios del sistema autónomo. Goodman & Gilman. Manual de farmacología y terapéutica, 2ed. McGraw-Hill Medical [Internet]. [citado 26 de febrero de 2017]. Disponible en: http://accessmedicina.mhmedical.com/content. aspx?bookid=1468§ionid=93491035
Rincón DA, Navarro JR. Entubación con inducción de secuencia rápida: Recomendaciones para el manejo de la vía aérea [Internet]. Rev Colom Anestesiología. 2004;32(2):89-104
Lymperopoulos A. Physiology and pharmacology of the cardiovascular adrenergic system. Front Physiol. 2013;4:240.
Mongardon N, Dyson A, Singer M. Pharmacological optimization of tissue perfusion. Br J Anaesth. 2009;103(1):82-88.