Clinical and epidemiological characterization of patients with a diagnosis of immunoglobulin A nephropathy. Health promoting company Susalud, 2004-2007
Article Sidebar
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Downloads
Societal impact
Main Article Content
Abstract
Introduction: IgA nephropathy is a mesangial proliferative glomerular disease, mediated by immune complexes, due to the deposition of type A globulin; it is regarded as the first cause of primary glomerulonephritis in the world.
Objective: To describe the clinical and epidemiological profile of patients with a diagnosis of immunoglobulin nephropathy in the Heatlh Promoting Company SUSALUD, during the period of 2004-2007
Methods: A study of a clinical series was carried out in patients older than 14 years who had a diagnosis of Inmunoglobulin A Nephropathy confirmed by renal biopsy and who belonged to the Heatlh Promoting Company Susalud in the city of Medellin during the years 2004 to 2007; the information about the variables was extracted from the medical histories of the patients and thereafter processed in a database in the statistical package SPSS 11.0, with which the analysis of information was also performed.
Results: In this study of 75 patients with Chronic Kidney Disease, the investigation group found that female gender was predominant (60%), arterial hypertension coexisted with Immunoglobulin A Nephropathy in three out of every five patients. Investigation group observed that one in every two patients had proteinuria of 1 gram and more, and 28% of patients in this series were diagnosed with the nephrotic syndrome.
Conclusion: This study allows establishing that in this group of patients with IgA nephropathy some clinical characteristics are different to those found in other studies worldwide.
Article Details
References
D’Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med. 1987; 245:09-27.
Julian BA, Waldo FB, Rifai A, Mestecky J. IgA nephropathy, the most common glomerulonephritis worldwide: a neglected disease in the United States. Am J Med. 1988; 84:129-32.
Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 Report. JAMA 2003; 289: 2560- 72.
Shen P, He L, Huang D. Clinical course and prognostic factors of clinical early IgA nephropathy. Neth J Med. 2008; 66(6):242-7.
Shen P, He L, Li Y et al. Natural history and prognostic factors of IgA nephropathy presented with isolated microscopic hematuria in Chinese patients. Nephron Clin Pract. 2007; 106(4):157-61.
Woo KT, Edmondson RP, Wu AY, Chiang GS, Pwee HS, Lim CH. The natural history of IgA nephritis in Singapore. Clin Nephrol. 1986; 25(1):15-21.
Coppo R, D’Amico G. Factors predicting progression of IgA nephropathies. J Nephrol. 2005; 18(5):503-12.
Ibels LS, Györy AZ. IgA nephropathy: analysis of the natural history, important factors in the progression of renal disease, and a review of the literature. Medicine. 1994; 73(2):79-102.
Nozawa R, Suzuki J, Takahashi A, et al. Clinicopathological features and the prognosis of IgA nephropathy in Japanese children on long-term observation. Clin Nephrol. 2005; 64(3): 171-9.
Alamartine E, Sabatier JC, Guerin C, et al. Prognostic factors in mesangial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses. Am J Kidney Dis. 1991; 18(1):12-9.
Lee HS, Lee MS, Lee SM, et al. Histological grading of IgA nephropathy predicting renal outcome: revisiting H. S. Lee’s glomerular grading system. Nephrol Dial Transplant. 2005; 20(2): 342-8.
Lee HS, Koh HI, Lee HB, et al. IgA nephropathy in Korea: a morphological and clinical study. Clin Nephrol. 1987; 27:131–40.
Lee SMK, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease. Hum Pathol. 1982; 13:314–22.
Meadow SR, Glasgow EF, White RHR, et al. Schönlein– Henoch nephritis. Q J Med. 1972; 41:241–58.
Lv J, Zhang H, Zhou Y, et al. Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: a long-term follow up of 204 cases in China. Nephrology. 2008; 13(3):242-6.