Perioperatory oxygen supplement and surgical wound infection: a meta-nalysis of randomized controlled trials
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Abstract
Objective: To systematically asses the evidence about high perioperatory oxygen doses efficacy and the surgical wound infection risk.
Data Sources: The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, LILACS, CINAHL, investigators contacts, books.
Selection Criteria: Randomized Controlled Trials which asses the oxygen high doses FIO2 ≥ 80% supplement during the transoperatory and at least two hours postoperatory with standard oxygen doses FIO2 ≤ 35% and evaluate the superficial surgical site infection at least fifteen days after surgery.
Data Collection and Analysis: The authors extracted the data in an independent way and evaluated the trials quality with the Jadad scale.
Main Results: Four trial involving 989 participants were included in this review. The administration of high FIO2 demonstrated no statistically significant reduction in the surgical site infection development. OR 0,79 IC 95% (0,34, 1,84) p value = 0,58 and with heterogeneity evidence X2 11,77 gl 3, p value = 0,008, I2 74,5%. On mortality OR 0,17 IC 95% (0,03, 0,98) p value = 0,05 and without heterogeneity evidence X2 0,01 gl 1, p value = 0,94, I2 0%. Hospital length of stay had a WMD 0,75 IC 95% (0,05, 1,45)) p value = 0,03 and without heterogeneity evidenced X2 2,74 gl 2, p = 0,25, I2 26,9%.
Conclusions: Results don’t support the use of high FIO2 in the management of electives patients whit abdominal surgery to reduce the surgical site infection and suggest it can reduce the global mortality.
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References
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