Central diabetes insipidus associated with empty sella syndrome. Report of a case Autores

Abstract

A 40 year old woman presented with a history of 14 years of polydipsia and poliuria preceded by frequent and severe headache. There was no history of psychiatric illness or diabetes mellitus. She presented galactorrea related to oligomenorrea and severe cephalea during 4 years after her last chilbirth. Galactorrea disappeared spontaneusly but shortly after the patient displayed marked poliuria and polidipsia. She then underwent surgery because of uterine myomas. Urine density was 1,002 and MRI of the sella turcica showed arachnoidocele (empty Sella Syndrome); growth hormone was at the lower extreme of normality. A dehydration test documented abundant diuresis with low urinary densities and marked serum hyperosmolarity; vasopressin application confirmed the diagnosis of diabetes insipidus.