Benign breast adenomyoepithelioma. Case report and literature review

Main Article Content

Oscar Alejandro Bonilla Sepúlveda

Abstract

The breast adenomyloepithelioma is an unusual tumor characterized by the biphasic proliferation of epithelial and myoepithelial cells. Although most of these tumors are benign, they may be at risk of local recurrence and few cases with malignant transformation may have chances of metastasis. The clinical and imaging diagnosis has no characteristic features and, in general, a complete resection of the lesion is required for microscopic study and support in immunohistochemistry. When risk of local recurrence is present, a resection with wide margins is recommended. The clinical history was the primary source of information on the case and, as a complement, there was a literature search, in both English and Spanish, focused on the use of the words “Breast” and “Adenomyoepithelioma” and was retrieved from Pubmed database publications from the last 10 years.

Keywords:
breast neoplasms, adenomyloepithelioma, immunohistochemistry, ultrasonography, mastectomy

Article Details

References

Tavassoli FA. Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991; 15(6):554-568.

Simpson PT, Gale T, Reis-Filho JS, Jones C, Parry S, Steele D, Cossu A, Budroni M, Palmieri G, Lakhani SR. Distribution and significance of 14-3-3 sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue. J Pathol. 2004; 202(3):274-85.

Iyengar P, Ali S, Edi Brogi. Fine niddle aspiration cytology of mammary adenomyopithelioma: A study of 12 patients. Cancer (Cancer Cytopathology). 2006; 108:250-6.

Gatti G, Viale G, Simsek S, Zurrida S, Intra M, Caldarella P, et al. Adenomyoepithelioma of the breast, presenting as a cancer. Tumori. 2004; 90:337-9.

Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Current Topics in Pathology. 1970; 53:161-220.

Khan L, Shrivastava S, Singh PK, Ather M. Benign breast myoepithelioma. J Cytol. 2013; 30:62-4.

Bult P, Verwiel JMM, Wobbes T, Kooy-Smits MM, Biert J, Holland R. Malignant adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor. Case report and review of the literature. Virchows Arch. 2000; 436:158-66.

Rosen PP. Adenomyoepithelioma of the breast. Hum Pathol. 1987; 18(12): 1232-7.

McLaren BK, Smith J, Schuyler PA, Dupont WD, Page DL. Adenomyoepithelioma: Clinical, histologic, and immunohistologic evaluation of a series of related lesions. Am J Surg Pathol. 2005; 29(10):1294-9.

Patchefsky AS, Hollander IJ. Adenomyoepithelioma of the breast: A spectrum of biologic behavior. Am J Surg Pathol. 1992; 16(9):868-76.

Ahmadi N, Negahban S, Aledavood A, Daneshbod K, Daneshbod Y. Malignant adenomyoepithelioma of the breast: A review. 2015; 21(3):291-6.

Erel S, Tuncbilek I, Kismet K, Kilicoglu B, Ozer E, Akkus MA. Adenomyoepithelial adenosis of the breast: Clinical, radiological, and pathological findings for differential diagnosis. Breast Care. 2008; 3:427-30.

Mouhsine A, Belkouch A, Atmane E, Rokhssi R, Berrada Y, Belyamani L, et al. Myoepithelial carcinoma of the breast developed in an adenomyoepithelioma: A case report. Int J Med Imaging. 2014; 2(5):109-11.

Yoon JY, Chitale D. Adenomyoepithelioma of the breast. A brief diagnostic review. Arch Pathol Lab Med. 2013; 137(5):725-9.

Gill TS, Clarke D, Douglas-Jones AG, Sweetland HM, Mansel RE. Adenomyoepithelioma of the breast: A diagnostic dilemma. Eur J Surg Oncol. 2000; 26:316-8.

Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, Van de Vijver MJ. WHO Classification of tumors of the breast. 4th edition. WHO Press; 2012.

Satyanarayana V, Gole S. Adenomyoepithelioma a rare breast tumor: Case studies with review of the literature. The Internet Journal of Pathology. 2012; 13:2.

Jian Z, Gaofeng N, Dan W, Qingqing H, Peifeng L. Lobulated adenomyoepithelioma: A case report showing immunohistochemical profiles. Int J Clin Exp Pathol. 2015; 8(11):15407-11.

Qureshi A, Kayani N, Gulzar R. Malignant adenomyoepithelioma of the breast: A case report with review of literature. BMJ Case Rep. 2009; Bcr01.2009.144

Han B, Mori I, Nakamura M, Wang X, Ozaki T, Nakamura K, Kakuda K. Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: Case report with immunohistochemical and mutational analysis. Pathol Int. 2006; 56(4):211-6

Loose JH, Patchefsky AS, Hollander IJ. Adenomyoepithelioma of the breast: A spectrum of biologic behavior. Am J Surg Pathol. 1992; 16(9):868-76.

Rosen PP. Myoepithelial neoplasms. In: Rosen’s Breast Pathology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2009:137-60.

Hayes MM. Adenomyoepithelioma of the breast: A review stressing its propensity for malignant transformation. J Clin Pathol. 2011; 64(6):477-84.

Papaevangelou A, Pougouras I, Liapi G. Cystic adenomyoepithelioma of the breast. Breast. 2004; 13(4):356-8.

Laforga JB, Aranda FI, Sevilla F. Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions. Diagn Cytopathol. 1998; 19(1):55-8.

Lee WY. Fine needle aspiration cytology of adenomyoepithelioma of the breast: A case indistinguishable from phyllodes tumor in cytological findings and clinical behavior. Acta Cytol. 2000; 44:488-90.

Petrozza V, Pasciuti G, Pacchiarotti A, Tomao F, Zoratto F, Rossi L, et al. Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements. World J Surg Oncol. 2013; 11:285.

Saad RS, Richmond L, Nofech-Mozes S, Ghorab Z. Fine-needle aspiration biopsy of breast adenomyoepithelioma: A potential false positive pitfall and presence of intranuclear cytoplasmic inclusions. Diagn Cytopathol. 2012; 40:1005-9.

Warrier S, Hwang S, Ghaly M, Matthews A. Adenomyoepithelioma with ductal carcinoma in situ: A case report and review of the literature. Case Rep Surg. 2013; 2013:521417

Choi SY, Kim JS, Kim SJ, Kim YJ, Kim L, Young UC. Malignant adenomyoepithelioma of the breast presenting as a large mass that grew slowly without metastasis. Journal of Breast Cancer. 2009; 12(3):219-22.

Khurana A, Jalpota Y. Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: A case report of a rare entity. Indian Journal of Pathology and Microbiology. 2010; 53(2):310-2.

Awamleh AA, Gudi M, Shousha S. Malignant Adenomyoepithelioma of the breast with lymph node metastasis: A detailed immunohistochemical study. Case Reports in Pathology. 2012; 2012:305858-305858.

Wiens N, Hoffman DI, Huang CY, Nayak A, Tchou J. Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: A single institution’s experience. Am J Surg. 2019; pii: S0002-9610(19)30363-0.

: Yuan Z, Qu X, Zhang ZT, Jiang WG. Lessons from managing the breast malignant adenomyoepithelioma and the discussion on treatment strategy. World J Oncol. 2017; 8(4):126- 31.

Howlett DC, Mason CH, Biswas S. Adenomyoepithelioma of the breast: Spectrum of disease with associated imaging and pathology. AJR Am J Roentgenol. 2003; 180:799-803.

Woodward WA, Chen MS, Behbod F, Rosen JM. On mammary stem cells. J Cell Sci. 2005; 118(Pt 16):3585-94

Most read articles by the same author(s)