Treatment of SAPHO syndrome with zoledronic acid: a case report

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Published: 2012-12-15

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Merino Correa, S., Tabares Quintero, C., Vargas Grajales, F., & Velásquez Franco, C. J. (2012). Treatment of SAPHO syndrome with zoledronic acid: a case report. Medicina UPB, 31(2), 193-200. https://revistas.upb.edu.co/index.php/medicina/article/view/1702
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Sara Merino Correa
Pontifical Bolivarian University image/svg+xml
Catalina Tabares Quintero
Pontifical Bolivarian University image/svg+xml
Francisco Vargas Grajales
Pontifical Bolivarian University image/svg+xml
Carlos Jaime Velásquez Franco
Pontifical Bolivarian University image/svg+xml

Abstract

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is a chronic and inflammatory condition, with cutaneous and osteoarticular manifestations. Its etiology is still unclear, although a possible association has been considered between this syndrome and spondylarthropathies. Several types of treatment with steroids and anti-inflammatory drugs are currently used for this condition, obtaining different results. Biphosphonates are a new treatment option for SAPHO syndrome due to their anti-osteoclastic and anti-inflammatory properties. We report the case of a male patient with SAPHO syndrome, who was successfully treated with zoledronic acid.

Keywords:
acquired hyperostosis syndrome, spondylarthropathies, diphosphonates

Article Details

Author Biographies

Sara Merino Correa, Pontifical Bolivarian University

Medical student. School of Health Sciences. Bolivarian Pontifical University. Medellin Colombia.

Catalina Tabares Quintero, Pontifical Bolivarian University

Medical student. School of Health Sciences. Bolivarian Pontifical University. Medellin Colombia.

Francisco Vargas Grajales, Pontifical Bolivarian University

Internist at the Pontificia Bolivariana University. Rheumatologist. University of Antioquia. Rheumatologist Reumatologya SA and Reumalab. Medellin Colombia.

Carlos Jaime Velásquez Franco, Pontifical Bolivarian University

Rheumatologist Internist. University of Antioquia. Assistant Professor of Chair. School of Health Sciences. Bolivarian Pontifical University. Rheumatologist Bolivariana University Clinic and Pablo Tobón Uribe Hospital. Medellin Colombia.

References

Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G, Prost A. Acne-pustulosis-hyperostosisosteitis syndrome of a national survey: 85 cases. Rev Rheum Mal Osteoartic. 1987;54:187–196.

Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, et al. HORIZON Pivotal Fracture Trial.Onceyearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007;356:1809-1822.

Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, et al. HORIZON Recurrent Fracture Trial Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med. 2007;357:1799-1809.

Davis JC, Huang F, Maksymowych W. New therapies for ankylosing spondylitis: etanercept, thalidomide, and pamidronate. Rheum Dis Clin N Am. 2003;29:481–494.

Soubrier M, Dubost JJ, Ristori JM, Sauvezie B, Bussiere JL. Pamidronate in the treatment of diffuse sclerosing osteomyelitis of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2001;92:637–640.

Guignard S, Job-Deslandre C, Sayag-Boukris V, Kahan A. Pamidronate treatment in SAPHO syndrome. Joint Bone Spine.2002;69:392–396.

Kopterides P, Pikazis D, Koufos C. Successful treatment of SAPHO syndrome with zoledronic acid. Arthritis Rheum.2004;50:2970-2973.

Giedion A, Holthusen W, Masel LF, Vischer D. Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol (Paris).1972;15:329–342.

Earwaker JW, Cotten A. SAPHO: syndrome or concept? Imaging findings. Skeletal Radiol. 2003;32:311–327.

Szanto E, Linse O. Arthropathy associated with palmoplantar pustulosis. Clin Rheumatol. 1991;10:130- 135.

Tagaki M, Oda J, Tsuzuki N, Sonozaki H. Palmoplantar pustulotic arthro-osteitis of the peripheral joints with no sternocostoclavicular lesions. Ann Rheum Dis.1992; 51:558-560.

Self SJ, Montes LF. Follicular occlusion triad. South Med J. 1970;63:156-160.

Taccari E, Spadaro A, Riccieri V, Guerrisi R, Guerrisi V, Zoppini A. Sternoclavicular joint disease in psoriatic arthritis. Ann Rheum Dis. 1992;51:372-374.

Rojas A, Rondón Herrera F, Restrepo Suarez JF. Síndrome SAPHO. Rev Col Reumatol. 2002;9:56-61.

Kahn MF, Khan MA. The SAPHO syndrome. Baillieres Clin Rheumatol.1994;8: 333–362.

Serushan M, Spencer PL, Yeh WLS, Kaminski M. Osteomyelitis of cervical spine from Propionibacterium acnes. Arthritis Rheum.1982;25:346-348.

Gerster JC, Lagier R, Livio JJ. Propionibacterium acnes in spondylitis with palmoplantar pustulosis. Ann Rheum Dis.1990;49:337-339.

Maugars Y, Berthelot JM, Ducloux JM, Prost A. SAPHO syndrome: a follow-up study of 19 cases with special emphasis on enthesis involvement. J Rheumatol. 1995;22:2135-2141.

Kahn MF. Why the “SAPHO” syndrome? J Rheumatol.1995;22:2017-2019.

Reith JD, Bauer TW, Schils JP. Osseous manifestations of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. Am J Surg Pathol.1996;20: 1368- 1377.

Pauli SL, Kokko ML, Suhonen R. Acne fulminans with bone lesions. Acta Derm Venereol.1988;68:351-355.

Brandt J, Marzo-Ortega H, Emery P. Ankylosing spondylitis: new treatment modalities. Best Pract Res Clin Rheumatol. 2006;20:559-570.

Marshall H, Bromilow J, Thomas AL, Arden NK. Pamidronate: a novel treatment for the SAPHO syndrome? Rheumatology. 2002;41:231–233.

Courtney PA, Hosking DJ, Fairbain KJ, Deighton CM. Treatment of SAPHO with pamidronate. Rheumatology. 2002;41:1196–1198.

Kerrison C, Davidson JE, Cleary AG, Beresford MW. Pamidronate in the treatment of childhood SAPHO syndrome. Rheumatology.2004;43:1246–1251.

Amital H, Applbaum YH, Aamar S, Daniel N, Rubinow A. SAPHO syndrome treated with Pamidronate: an open- label study of 10 patients. Rheumatology. 2004;43:658-661.

Ichikawa J, Sato E, Haro H, Ando T, Maekawa S, Hamada Y. Successful treatment of SAPHO syndrome with an oral bisphosphonate. Rheumatol Int.2009;29:713–715.

Kopterides P, Pikazis D, Koufos C. Successful treatment of SAPHO syndrome with zoledronic acid. Arthritis Rheum. 2004;50:2970-2973.

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