Efecto genotóxico y mutagénico de contaminantes atmosféricos
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Cada día, con los avances de la industria, las zonas urbanas incrementan la concentración y número de contaminantes, por ende, se exceden los valores permisibles (100 mg/m3 ) y se altera la sensibilidad de los organismos y se crean las condiciones para desarrollar mutaciones y cáncer. Históricamente, la exposición del hombre a una gran variedad de mezclas complejas se ha asociado con el aumento del riesgo para generar mutaciones y cáncer. La contribución sobre el riesgo para la salud, que ejerce la contaminación atmosférica, presenta dificultades en la identificación de los componentes tóxicos de las mezclas complejas y el poco conocimiento acerca del comportamiento de las sustancias genotóxicas encontradas en ellas.
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USEPA. Selecting exposure routes and contaminants of concern by risk-based screening. EPA.1993;903: R-93-001.
Williams GM, Weisburger JH. Interactions of chemical carcinogens: environmental mutagens and carcinogens. New York : A.R. Liss Publ ; 1988. p. 288-94.
Biava PM, Audisio R, Centonze A, Barbieri A, Bisanti L, Duca G. An epidemiological study of the health conditions of Milan traffic police with respect to pollution from vehicular traffic. Med Lav.1992;83(3):249–58.
Kotin P, Falk H, Thomas M. Aromatic hydrocarbons III Presence in the particulate phase of diesel engine exhaust and the carcinogenecity of exhaust extracts. Arch Ind Health.1995; 11:113–20.
Zhao X, Niu J, Wang Y, Yan C, Wang X, Wang J. Genotoxicity and chronic health effects of automobile exhaust: a study on the traffic policemen in the city of Lanzhou.Mutat Res. 1998;415:185–90.
Marston P, Ferguson J, Fischer K. Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hidrocarbons (PAH) on the tumor initiation, PAH-ADN binding and metabolic activation of carcinogenic PAH en mouse epidermis. Carcinogenesis. 2001;22(7):1077-86.
Kumarb S, Jyh-Ming L, Whysnera J, Harish C, Sikka S. Mutagenicity of benzo[b]phenanthro[2,3-d]thiophene (BPT) and its metabolites in TA100 and base-specific tester strains (TA7001–TA7006) of Salmonella typhimurium: evidence of multiple pathways for the bioactivation of BPT. Mut Res.2004;545:11–21.
Casona F, Bocchia C, Martinob A, Pintoa G, Fontanaa F. The Salmonella mutagenicity of urban airborne particulate matter (PM2.5) from eight sites of the EmiliaRomagna regional monitoring network (Italy). Sci Total Environ.2004;324(3):79-90
Wesp HF, Tang X, Edenharder R. The influence of automovile exhausts on mutagenicity of soils: contamination with fractionation, separation, and preliminary identification of mutagens in the Salmonella/ reversion assay and solvent fractions on the sisterchromatid exchanges in human lymphocyte culture and in the in vivo mouse bone marrow micronucleus assay. Mutat Res.2000;472:1-21.
Flowers-Geary L, Bleczinski W, Harvey RG, Penning TM. Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon o-quinones produced by dihydrodiol dehydrogenase. Chem Biol Interact.1996;99:55-72.
Xue W, Warshawsky E. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review. Toxicol Appl Pharmacol.2005; 206:73-93.
Arbex MA, Cançado JED, Pereira LAA, Braga ALF, Saldiva PHN. Queima de biomassa e efeitos sobre a saúde.J Bras Pneumol.2004;30(2):158-75.
Environmental Protection Agency (United States). Washington: Environmental Protection Agency; 2004.
Lippmann M. Air pollution and health : studies in the Americas and Europe : air pollution & Health in Rapidly Developing Countries. London: Earthscan Publications ; 2003.
Centro Panamericano de Ingeniería Sanitaria y Ciencias del Ambiente. Introducción a la Toxicología de la contaminación del aire. Lima : CEPIS ;2002
Seoánez M. Tratado de la contaminación atmosférica: problemas, tratamiento y gestión. Madrid: MundiPrensa; 2002.
Watanabe T, Shiozawa YT, Takahashi Y, Nukaya H, Terao Y, Hirayama T, et al. Seasonal fluctuation of mutagenicity of river water in Fukui Japan and the contribution of 2-phenylbenzotriazole-type mutagens. Mutat Res. 2003;519: 187-97.
Bolognesi C, Lando C, Forni A, Landini E, Scarpato R, Migliore L, et al. Chromosomal damage and ageing: effect on micronucleus frequency in peripheral blood lymphocytes.Age Ageing.1999;28:393–97.
Boström CE, Gerde P, Hanberg A, Jernström B, Johansson C, Kyrklund T, Rannug A, Törnqvist M, Victorin K, Westerholm R. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect.2002;110 (3):451–88.
Nakayama A, Koyoshi S, Morisawa S, Yagi T. Comparison of the mutations induced by pbenzoquinone, a benzene metabolite, in human and mouse cells.Mutat Res.2000;470:147-53.
Feilberga A, Nielsena T, Binderupb M, Skovc H. Observations of the effect of atmospheric processes on the genotoxic potency of airborne particulate matter. Atmos Environ.2002;36: 4617–25.
Zhaoa H, Bargera M, Mab J, Castranovaa V. Effects of exposure to diesel exhaust particles (DEP) on pulmonary metabolic activation of mutagenic agents. Mut Res.2004;564:103–13. 23. Somers C, Yauk C, White P, Parfett C, Quinn J. Air pollution induces heritable DNA mutations. PNAS.2002;99(25):15904-07.
Bustamante O, Varona M, Patiño RI, Groot H, Sicard D, Tórres M, Pardo D. Exposición a solventes orgánicos y efectos genotóxicos en trabajadores de fábricas de pinturas en Bogotá. Rev Salud Pública.2007; 9(2):275- 88.
Varona M, Cárdenas O, Conde JV, Rossi LV, Idrovo AJ, Araque A. Determinación de la exposición en trabajadores que laboran con solventes orgánicos en Bogotá. Bogotá: INS; 2001.
Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mut Res. 2002;521:201-8.
Klumpp A, Ansel W, Klumpp G. A Pan-European biomonitoring network for urban air quality assessment,environmental management strategies. Environ Sci & Pollut Res (ESPR). 2002; 9(3):199- 203.
Pohjola K, Lappi M, Honkanen M, Rantanen L. DNA binding of polycyclic aromatic hydrocarbons in a human bronchial epithelial cell line treated with diesel and gasoline particulate extracts and benzo[a]pyrene. Mutagenesis.2003;18(5):429-38.
Volker M. 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution. Mutagenesis.2005;20(6):399-410.
Lyons, France. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: overall evaluations of carcinogenicity. Lyon : World Health Organization ; 1987
Eskenazi B, Castorina R. Association of prenatal maternal or postnatal child environmental tobacco smokes exposure and neurodevelopmental and behavioral problems in children. Environ Health Perspect.1999;107:991–1000.
Marini D. Mutation spectra of complex mixtures.Mutat Res.1998;411:11-18.
Donnelly KC, Safe SH, Randerath K, Randerath E. Bioassay-based risk assessment of complex mixtures. J Hazard Mater.1995;41:341-50.
Koss G, Tesseraux I. Toxicology. San Diego: Academia Press; 1999. p. 603-44.
Vives I, Grimalt JO, Guitart R. Los hidrocarburos aromáticos policíclicos y la salud humana. Apuntes de Ciencia y Tecnología.2001;3:45-51.
Environmental Protection Agency (United States). Toxics release inventory public data release report, Office of information analysis and access [Internet]. Washington:EPA; 2001 [acceso 10 de Octubre de 2008]. Disponible en: http://www.epa.gov/tridata/index. htm.
Organización Mundial de la Salud. Air quality guidelines for Europe. 2. ed. Copenhagen: WHO; 2000.
Feola G. Salud y Ambiente en las Américas: recopilación preliminar de indicadores y desafíos para un enfoque integrador. Reunión de Ministros de Salud y Ambiente de las Américas. Ottawa: IDRC; 2006.
Romieu I. Outdoor air pollution and a cute respiratory infection among children in developing countries.J Occup Environ Med.2002; 44(7):640-9.
Stemermann G. The pathology of breast cancer in Japanese women compared to other ethnic groups. Breast Cancer Res Treat.1991;18:567–72.
Coleman M, Esteve J, Damiecki P, Arslan A, Renard H. Trends in cancer incidence and mortality. Geneva; WHO;1993..
Devivo I, Maríon M, Smith S, Carney P, Brandt W. Mutant c-K-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride. Cancer Causes Control.1994;5:273–78.
Kakizoe T. Cancer Statistics in Japan FPCR publication. Tokyo : FPCR; 1997
Hartman A, Blaszyk H, KovachJ J , Sommer S. Epidemiology of p53 gene mutations in human breast cancer.Trends Genet.1997;13(1):27-33.
Setlow R. Human cancer: etiologic agents/dose responses/DNA repair/cellular and animal models.Mut Res. 2001; 477:1–6. 46. Ferguson L. Natural and human-made mutagens and carcinogens in the human diet. Toxicology. 2002;181- 182:79–82.
Wogan N, Hecht S, Felton J, Conney A, Loeb A. Environmental and chemical carcinogenesis. Semin Cancer Biol.2004;14:473–86.
Minamoto T, Mai M, Ronai Z. Environmental factors as regulators and effectors of multistep Carcinogenesis. Carcinogenesis.1999; 20:519–27.
Singh P, Kant L, Shah B, Muthuswamy V. Indoor air pollution in INDIA: a major environmental and public health concern. ICMR Bull. 2001;31(5).
Levine A. The tumor suppressor genes. Annu Rev Biochem.1993;62:623 -51.
Robert V, Michel P, Flaman J, Chiron A, Martin C, Charbonnier F, et al. High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis. Carcinogenesis.2000;21:563–65.
Larue M, Allard P, Simoneau M, Normand C, Pfister C, Moore L, et al. P53 point mutations in initial superficial bladder cancer occur only in tumours from current or recent cigarette smokers.Carcinogenesis.2000;21:101- 6.
Diaz R, Lopez D, Garcia A, Yoon A, Matthews J, Mangues R, et al. Complex effects of Ras proto-oncogenes in tumorigenesis.Carcinogenesis.2004;25:535-39.
Sung S, Turner L, McCarthy S, Enkemann S, Li C, Yan P, et al. Oncogene regulation of tumor suppressor genes in tumorigenesis.Carcinogenesis.2005; 26:487-94.
Bell D, Thompson C, Taylor J, Miller C, Perera F, Hsieh L , et al. Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu.Environ Health Perspect.1992;98:113–17.
Nakajima T, Elovaara E, Anttila S, Hirvonen A, Camus A, Hayes J, et al. Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. Carcinogenesis.1995;16:707–11.
Kato S, Shields P, Caporaso N, Hoover R, Trump F, Sugimura H, et al. Cytochrome P450 IIE1 genetic polymorphisms, racial variation and lung cancer.Cancer Res.1992;52:6712–15.
Oyama T, Kawamoto T, Mizoue T, Sugio K, Kodama Y, Mitsudomi T, et al. Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.Anticancer Res.1997;17:583–88.
Hayashi S, Wantanbe J, Nakachi K, Kawajiri K. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem.1991;110: 407–11.
Hartwell H, Kastan L. Cell cycle control and cancer. Science.1994;266: 1821–28.
Poirier M, Beland F. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adductbased human cancer risk assessment. Chem Res Toxicol.1992;5:749 – 55.
Poirier M, Beland F. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents.Environ. Health Perspect.1994;102(2):161- 65.
Kamedaa T, Inazub K, Bandowc H, Sanukidaa S. Diurnal change of direct-acting mutagenicity of soluble organic fraction of airborne particles collected at Southern Osaka: correlation between the mutagenicity, particles-associated nitroarenes, and gaseous emission.Atmos Environ.2004; 38:1903–12.
González R, Romay C, Díaz S. Estudios sobre genotoxicidad del ozono.Rev Cubana Invest Biomed.2004; 23(3):177-83.
Hengstler JG. Nueva categorización de los carcinógenos genotóxicos. Leipzig: Sociedad Iberoamericana de Información Científica; 2007.
Du Four A, Van Larebeke N, Janssen C. Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium.Mut Res.2004;558:155–67.
World Health Organization. Air quality guidelines for Europe 2001. Copenhague: WHO; 2001.
Valko M, Morris H, Cronin M.T.D. Metals, toxicity and oxidative stress.Curr Med Chem. 2005;12:1161- 1208.
Vousden KH, Lu X. Live or let die: the cell’s response to p53.Nat Rev Cancer.2002; 2:594–604.
Bishop J. Molecular themes in oncogenesis. Cell.1999;64:235 –48.