The Alzheimer’s connection: Where is it? Insights from Quantitative Proteomics

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Published: 2011-06-15

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Mejía, S., Osorio, C., Londoño, C., Booe, J., Jeong, S., & Álzate, Óscar. (2011). The Alzheimer’s connection: Where is it? Insights from Quantitative Proteomics. Medicina UPB, 30(1), 48-65. https://revistas.upb.edu.co/index.php/medicina/article/view/1928
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Sergio Mejía
University of North Carolina School of Medicine image/svg+xml
Cristina Osorio
University of North Carolina School of Medicine image/svg+xml
Carolina Londoño
University of North Carolina School of Medicine image/svg+xml
Jessica Booe
University of North Carolina
SunYong Jeong
University of North Carolina
Óscar Álzate
University of North Carolina

Abstract

In this review we present the basic concepts that define the pathology of Alzheimer Disease (AD) and the fundamental methods used in Neuroproteomics for its study. Some results in the analysis of this disease are discussed and their relationship with the APOE4 allele of APOE, the gene coding for the APOE4 genotype of the Apolipoprotein E (ApoE). Finally we present some general considerations on AD, how to avoid the progression and we discuss briefly about the future of research in this area.

Keywords:
Alzheimer disease, apolipoprotein E, oxidative stress, proteomics/methods, mass spectrometry, proteomics

Article Details

Author Biographies

Sergio Mejía, University of North Carolina School of Medicine

Medical, PhD. System Proteomics Center, School of Medicine University of North Carolina at Chapel Hill. Chapel Hill, NC, USAMédico, PhD. System Proteomics Center, Facultad de Medicina de la Universidad de Carolina del Norte en Chapel Hill. Chapel Hill, Carolina del Norte, Estados Unidos

Cristina Osorio, University of North Carolina School of Medicine

Psychology Systems Proteomics Center, Facultad de Medicina de la Universidad de Carolina del Norte en Chapel Hill. Chapel Hill, Carolina del Norte, Estados Unidos.

Carolina Londoño, University of North Carolina School of Medicine

Biomedical Engineer, MSc Systems Proteomics Center, De of Cell and Developmental Biology. School of Medicine University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.

Jessica Booe, University of North Carolina

Student. Systems Proteomics Center, Department of Cell and Developmental Biology School of Medicine. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.

SunYong Jeong, University of North Carolina

PhD System Proteomics Center - Department of Cell and Developmental Biology School of Medicine University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.

Óscar Álzate, University of North Carolina

PhD System Proteomics Center - Program in Moleculary Biology and Biotechnology - Departament of Cell and Developmental Biology, School of Medicine. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA. Proteomics Laboratory, Faculty of Medicine. Bolivarian Pontifical University. Medellin Colombia.

References