Characterization of patients with suspected invasive aspergillosis studied by Platelia test

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Published: 2010-12-15

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Olaya, V., Cadavid, C. M., Arango, K., Zuluaga, A., Durango, G. E., Uribe, J. D., Ramírez, J. D., & Agudelo, C. A. (2010). Characterization of patients with suspected invasive aspergillosis studied by Platelia test. Medicina UPB, 29(2), 109-118. https://revistas.upb.edu.co/index.php/medicina/article/view/2026
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Viviana Olaya
Pontifical Bolivarian University image/svg+xml
Clara Marcela Cadavid
Pontifical Bolivarian University image/svg+xml
Karen Arango
Corporación para Investigaciones Biológicas image/svg+xml
Alejandra Zuluaga
Corporación para Investigaciones Biológicas image/svg+xml
Gloria Elena Durango
San Vicente de Paúl University Hospital
Juan David Uribe
Santa Maria Cardiovascular Clinic
Juan David Ramírez
Pontifical Bolivarian University image/svg+xml
Carlos Andrés Agudelo
Pontifical Bolivarian University image/svg+xml

Abstract

Objective: to describe the characteristics of patients with suspected IA, who were studied with the platelia test as well as the results according to different diagnostic categories.


Methods: the medical records of patients with suspected IA treated at health facilities in Medellin who were tested with platelia were retrospectively reviewed. Clinical data, imaging, microbiology and the platelia test results were collected and descriptively analyzed.


Results: we included 78 patients treated from 2006 to 2008. IA was diagnosed in 21 (26.9%) patients and colonization was found in 8 (10.3%) patients. The acute invasive pulmonary form was found in 17 (81.0%), disseminated form in three (14.3%). Fever and dyspnea were the principal manifestation. Nodules were found more frequently in lung tomography. The tests were positive in 31 (39.7%) patients and in 50% of colonized patients. In 17 (47.2%) of 36 patients who received beta-lactam antibiotics, the test showed a positive result.


Conclusions: IA can be found in up to one third of patients with clinical suspicion, but diagnosis remains difficult because of the nonspecific clinical picture, coupled with the difficulty for obtaining clinical samples and the poor performance of diagnostic tests.

Keywords:
Aspergillus, Aspergillosis, galactomannan, invasive pulmonary aspergillosis

Article Details

Author Biographies

Viviana Olaya, Pontifical Bolivarian University

Physician, Resident of the specialization in Internal Medicine. Faculty of Medicine, Universidad Pontificia Bolivariana. Medellin Colombia.

Clara Marcela Cadavid, Pontifical Bolivarian University

Physician, Resident of the specialization in Internal Medicine. Faculty of Medicine, Universidad Pontificia Bolivariana. Medellin Colombia.

Karen Arango, Corporación para Investigaciones Biológicas

Laboratory analyst Medical and experimental mycology. Corporation for Biological Research. Medellin Colombia.

Alejandra Zuluaga, Corporación para Investigaciones Biológicas

Laboratory analyst Medical and experimental mycology. Corporation for Biological Research. Medellin Colombia.

Gloria Elena Durango, San Vicente de Paúl University Hospital

Bacteriologist specializing in Mycology. San Vicente de Paúl University Hospital. Medellin Colombia.

Juan David Uribe, Santa Maria Cardiovascular Clinic

Intensive Care Physician. Santa María Cardiovascular Clinic. Medellin Colombia.

Juan David Ramírez, Pontifical Bolivarian University

Internist. Bolivarian University Clinic and San Vicente de Paúl University Hospital. Medellin Colombia.

Carlos Andrés Agudelo, Pontifical Bolivarian University

Internist. Universidad Pontificia Bolivariana and Corporation for Biological Research. Medellin Colombia.

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