Non vertebral osteoarticular infections by Candida spp. in a hospital of high complexity in Medellín, Colombia
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Abstract
Objective: To describe the clinical and demographical characteristics of patients with osteomyelitis due to Candida spp. in Hospital Pablo Tobón Uribe in Medellín.
Methodology: Observational, descriptive study.
Results: Thirty patients were found to have osteomyelitis due to Candida spp. Of these, 70% were male, with a mean age of 49.9 years. 46% had a history of some type of immunosuppression; 60% had osteomyelitis due to Candida spp. where it was the only microorganism isolated and 40% had concomitant bacterial osteomyelitis. One patient had candidemia. 46% had previously undergone surgery and 26% had had some type of osteosynthesis material. Twenty-six patients (86%) had previously received antibiotics, where carbapenems, piperacillin, tazobactam, and vancomycin were the most frequently used. The long bones were the most affected osseous segments (33%). Non-albicans Candida was 63% and Candida spp. 3.3%. The most frequent of non-albicans Candida was Candida parapsilosis in 57%. 97% of isolations were sensitive to fluconazole and voriconazole. 46% finished treatment. Follow-up data were not collected from 43%, while 6.6% did not finish treatment.
Conclusions: As osteomyelitis due to Candida is increasing, analytic studies are warranted to explore associated risk factors. There was also an increase in non-albicans Candida compared to that which has been described in the literature, and only one case was found to have intermediate sensitivity to fluconazole.
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