Cutaneous manifestations in three patients with systemic amyloidosis
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Abstract
Systemic amyloidosis is a group of heterogeneous diseases caused by tissue deposition of misfolded proteins. We report 3 cases of patients with systemic amyloidosis. Diagnosis in all cases was confirmed by biopsy. Here, we also briefly review the pathogenesis, diagnosis, treatment, and clinical manifestations, with a particular focus on cutaneous manifestations. Since such lesions appear early in the disease, we consider that accurately identifying them can have an impact on the prognosis of this affection.
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Schreml S, Szeimies RM, Vogt T, Landthaler M, Schroeder J, Babilas P. Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Eur J Dermatol. 2010; 20 (2): 152–60.
Alvarez-Ruiz SB, García-Río I, Daudén E. Amiloidosis sistémicas. Actas Dermosifiliogr. 2005; 96 (2): 69–82.
Lestre S, Gonçalves A, João A, Ferreira A, Apetato M. Purpura: primary systemic amyloidosis manifestation. Acta Med Port. 2009; 22(3):307–12.
Schreml S, Szeimies RM, Landthaler M, Babilas P. Cutaneous amyloidosis. Hautarzt. 2011; 62(1):55–61.
Wang XD, Shen H, Liu ZH. Diffuse haemorrhagic bullous amyloidosis with multiple myeloma. Clin Exp Dermatol. 2008; 33(1):94–6.
Lutz ME, Pittelkow MR. Progressive generalized alopecia due to systemic amyloidosis. J Am Acad Dermatol. 2002; 46(3):434–6.
Obici L, Perfetti V, Palladini G, Moratti R, Merlini G. Clinical aspects of systemic amyloid diseases. Biochim Biophys Acta. 2005; 10 (1): 11–22.
Oliveira EV, Pozetti AC, Pozetti EM, Antonio JR, Michalany NS. Primary systemic amyloidosis associated with multiple myeloma. An Bras Dermatol. 2012; 87(1):119–22.
Silverstein SR. Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis. Dermatol Online J. 2005; 11(1):5.
Lachmann HJ, Hawkins PN. Systemic amyloidosis. Curr Opin Pharmacol. 2006; 6 (2):214–20.