Hepatitis Prevalence and Associated Factors for Coinfection with Other Infectious Markers in Blood Bank, 2006-2011

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Published: 2013-12-15

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Cruz Bermúdez, H. F., Angarita Fonseca, A., Restrepo Sierra, M. P., & Forero, S. E. (2013). Hepatitis Prevalence and Associated Factors for Coinfection with Other Infectious Markers in Blood Bank, 2006-2011. Medicina UPB, 32(2), 121-128. https://revistas.upb.edu.co/index.php/medicina/article/view/1520

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Author Biographies

Harold Fabián Cruz Bermúdez, Colombia Hematology Foundation

Specialist in Applied Statistics. Director of Research, Fundación Hematológica Colombia. Bogota Colombia.

Adriana Angarita Fonseca, Private practice

Master in Epidemiology, epidemiological advisor. Private practice. Bogota Colombia.

Mónica Patricia Restrepo Sierra, Colombia Hematology Foundation

Health services management specialist. President Fundación Hematológica Colombia. Bogota Colombia.

Sandra Erika Forero, Colombia Hematology Foundation

Bacteriologist and clinical laboratory worker. National operative supervisor Fundación Hematológica Colombia. Bogota Colombia.

Main Article Content

Harold Fabián Cruz Bermúdez
Colombia Hematology Foundation
Adriana Angarita Fonseca
Private practice
Mónica Patricia Restrepo Sierra
Colombia Hematology Foundation
Sandra Erika Forero
Colombia Hematology Foundation

Abstract

Objective: To establish the prevalence of hepatitis B and C and factors related to coinfection with other markers screened in blood bank volunteer donors between 2006 and 2011 in a blood bank in Colombia.


Methods: Retrospective cross-sectional study. The study population consisted of 587.446 records of volunteer blood donors, of which 13.133 showed reactivity to hepatitis B and/ or hepatitis C; odds ratios were calculated to establish factors associated with coinfection.


Results: The mean age was 38.55 ± 12.4. The odds ratios for simultaneous coinfection with other blood bank markers and analyzed variables were membership scheme 1.1 (1.04 to 1.36), gender 1,4 (1.22 – 1.61), and age 4.2 (3.54 to 4.99) for hepatitis B, and age 0.6 (0.38-1.00) and gender 5.1 (3.07-8.78) for hepatitis C.


Conclusions: This study demonstrates that age is a risk factor for simultaneous reactivity with other screening markers in blood banks. A different behavior was found between gender according to existing coinfection studies.

Keywords:
hepatitis B, hepatitis C, coinfection, blood donors, screening

References

Zarkesh E, Kardi M, Edalati M. Hepatitis C virus genotype frequency in Isfahan province of Iran: a descriptive cross-sectional study. Virol J. 2010; 7:69-74.

Zuckerman JN, Zuckerman AJ. Current topics in hepatitis B. J Infect. 2000; 41: 130-136.

Simmonds P. Genetic diversity and evolution of hepatitis C virus 15 years on. J Gen Virol. 2004; 85: 3173-3188.

Arroyo JA, Estrada JJ, Rojo J. Prevalencia del virus de la Hepatitis B en donadores de sangre mexicanos. Rev Med Hosp Gen Mex. 2010; 73 (2): 83-87.

Kleinman SH, Kuhns MC, Todd DS, Glynn SA, McNamara A, DiMarco A, et al. Frequency of HBV DNA detection in US blood donors testing positive for the presence of anti- HBc: implications for transfusion transmission and donor screening. Transfusion. 2003; 43: 696-704.

Margolis H, Alter M, Hadler S. Hepatitis B: evolving epidemiology and implications for control. Semin Liver Dis. 1991; 11:84-92.

Suárez A, Riestra S, Rodríguez M, Linares A, Otero L, Rodrigo L. A comparative analysis of blood donors with antibodies to the hepatitis C virus, positivity for the hepatitis B surface antigen and hypertransaminasemia in Asturias. Med Clin (Barc) 1994; 103:209-213.

González FL, Boccato RS, Pedro J, Papaiordanou PM, De Souza CA, Pellegrino-Junior J, et al. Prevalence of HbsAg anti-HBc and anti-HVC in blood donor candidates at the Campinas Hemocenter. Rev Inst Med Trop Sao Paulo. 1993;35:45-51.

Ling AE, Robbins KE, Brown TM, Dunmire V, Thoe SY, Wong SY, et al. Failure of routine HIV-1 tests in a case involving transmission with preseroconversion blood components during the infectious window period. JAMA. 2000; 284: 210- 14.

Mortier PP. Test for infection with VIH slandered goods. BMJ. 1988;296:1615 1616.

Abe Y, Kimura K, Horiuchi A, Miyake M, Kimura S. Improvement of ELISA sensitivity by allogenic adsorption of polyclonal antibodies: a technical note for nonexperts. Clin Chem Acta. 1994; 224:103–105.

Buseri FI, Muhibi MA, Jeremiah ZA. Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, South-West Nigeria. Blood Transfus. 2009; 7 (4): 293-299.

Méndez SN, Bautista GH, Sánchez RH, Bordes J, Uribe EM. Prevalencia de la hepatitis B y C en donadores de sangre en un hospital de tercer nivel de la Ciudad de México. Salud Pública. Mex. 1999; 41:475-478.

Fuentes J, Roca O, Maldonado F, Guillén M. Seroprevalencia de enfermedades hemotransmisibles en donantes de sangre. Rev Peru Med Exp Salud Pública. 2002;2:13-20.

García BM. Seropositividad de VIH, VHB, VHC y Treponema pallidum en el Sureste de México. Rev Inv Clin Mex. 2006; 6: 567-572.

Vivas C, Torres GC, Aguilar BS. Prevalencia del virus de la Hepatitis B y C en personal médico de un hospital de tercer nivel. Rev Gastroenterol Mex. 1997; 62:108-112.

Carreto MA, Carrada T, Martínez MA. Seroprevalencia de VHB, VHC y VIH en donadores de sangre en Irapuato, México. Sal Pub Mex. 2002; 45 (supl 5): S690-S693.

Fano R, Hernández M, Jiménez E, Longres A. Marcadores serológicos causantes de pérdidas de donaciones. Rev Cub Med Mil.2002:41-45.