Características clínicas de pacientes hospitalizados com infecção por Covid-19 na Clínica Soma em Medellín, Colômbia

Conteúdo do artigo principal

Carlos Alberto Betancur Jiménez
Beatriz Elena Calle Lemos
Luisa García Vergara
Daniel Vásquez

Resumo

Objetivo: o vírus SARS-COV-2 chegou a Medellín em 9 de março de 2020, afetando 397.395 pessoas nesta cidade até 8 de outubro de 2021. Este estudo busca descrever o comportamiento clínico dos pacientes internados na Clínica Soma no período entre 1º de julho de 2020 e 31 de janeiro de 2021, bem como identificar variáveis clínicas e paraclínicas associadas à sua admissão na UTI e mortalidade.


Metodologia: coorte retrospectiva com dados de prontuários de adultos internados na Clínica Soma por Covid-19 entre 1º de julho de 2020 e 31 de janeiro de 2021.


Resultados: foram identificados 849 indivíduos adultos com Covid-19, dos quais 326 foram hospitalizados (38,4%), a mortalidade foi de 13%. Os fatores mais associados à gravidade foram dispneia, hipertensão arterial, doença cardiovascular, D-dímero elevado, desidrogenase lática, linfopenia e idade avançada.


Conclusões: nosso estudo mostrou um comportamento semelhante ao descrito em outros estudos no mundo frente às variáveis na admissão por Covid-19, que estão associadas a piores desfechos clínicos.

Palavras-chave:
pandemia, Covid19, pneumonia viral, Medellín

Detalhes do artigo

Biografia do Autor

Carlos Alberto Betancur Jiménez, Universidad CES

Universidade CES, Grupo de Investigação em Ciências Básicas. Medellín - Colômbia.

Beatriz Elena Calle Lemos, Clínica soma

Clínica soma. Medellín - Colômbia.

Luisa García Vergara, Clínica soma

Clínica Soma. Medellín, Colômbia.

Daniel Vásquez, Universidad CES

Grupo de investigação em Epidemiologia e Bioestadística, Universidad CES. Medellín, Colômbia.

Referências

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727–733.

Sivakorn C, Luvira V, Muangnoicharoen S, Piroonamornpun P, Ouppapong T, Mungaomklang A, et al. Case Report: Walking pneumonia in Novel Coronavirus Disease (Covid-19): Mild symptoms with marked abnormalities on chest imaging. Am J Trop Med Hyg. 2020; 102(5):940-942.

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Weisman J, BruceH, et al. First case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020; 382(10):929-936.

Rodríguez-Morales AJ, Gallego V, Escalera-Antezana JP, Mendez CA, Zambrano LI, Franco Paredes C, et al. Covid-19 in Latin America: The implications of the first confirmed case in Brazil. Travel Med Infect Dis. 2020; 35:101613.

Boletín Ministerio de Salud Pública de Colombia 052 de 2020.

Ramírez JD, Flórez C, Muñoz M, Hernández C, Castillo A, Gómez S, et al. The arrival and spread of SARS-CoV-2 in Colombia. J Med Virol. 2021; 93:1158.

World Health organization Novel Coronavirus – China disease outbreak news: Update 12 January 2020.

Ministerio de Salud y Protección Social. Boletín de Prensa No 086 de 2020.

Organización Mundial de la Salud. (2020). Covid-19: cronología de la actuación de la OMS. [en línea, consultado el 27 de abril de 2022]. Disponible en: https://www.who.int/es/news/ item/27 04-2020-who-timeline---covid-19.

Coronaviridae Study Group of the International Committee on Taxonomy of V The species. Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS CoV-2. Nat Microbiol. 2020; 5:536–544.

Ministerio de Salud y Protección Social de Colombia. CORONAVIRUS (Covid-19). [en línea, consultado el 27 de abril de 2022]. Disponible en: https://www.minsalud.gov.co/salud/publica/ PET/Paginas/Covid-19_copia.aspx.

Ji D, Zhang D, Xu J, Chen Z, Yang T, Zhao P, et al. Prediction for progression risk in patients with Covid-19 pneumonia: The call score. Clin infect Dis. 2020; 71(6):1393-1399.

Dai CL, Kornilov SA, Roper RT, Cohen-Cline H, Jade K, Smith B, et al. Characteristics and factors associated with coronavirus disease 2019 infection, hospitalization, and mortality across race and ethnicity. Clin Infect Dis. 2021: 10.14.20212803.

Yuan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He XE, et al. Clinical characteristics of Coronavirus disease-2019 in China. N Engl J Med. 2020; 382(18):1708-1720.

Averyod P, Gao M, Linsdson N, Hartmnan J, Watkinson P, Young D, et al. Association between preexisting respiratory disease and its treatment and severe Covid-19 a population cohort study. Lancet Resp Med. 2021; 9(8):909-923.

Gallagher J. Coronavirus: How long does it take to recover? BBC News. [en línea, consultado el 27 de abril de 2022]. Disponible en: https://www.bbc.com/news/health-52301633.

Bellan M, Patti G, Hayden E, Azzolina D, Pirisi M, Acquaviva A, et al. Fatality rate and predictors of mortality in an Italian cohort of hospitalized Covid-19 patients. Sci Rep. 2020; 10(1):20731.

Bertsimas D. Covid-19 mortality risk assessment: An international multi-center study. PloS One 2020:15: e0243262.

Sung WY, Kaplan RM. Why Do Countries’ Covid-19 Death Rates Vary So Much? MedPage Today. [en línea, consultado el 27 de abril de 2022]. Disponible en: https://www.medpagetoday.com/ infectiousdisease/covid19/86527

Matta S, Chopra KK, Arora VK. Morbidity and mortality trends of COVID 19 in top countries. Indian J Tuberc. 2020; 67(4):S167-S172.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069.

Richardson S, Hirsh JS, Narasinhan M, Crawford M, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidity, and outcomes among 5700 patients hospitalized with Covid-19 in the New York City area. JAMA 2020; 323(20):2052-2059.

Dawson P, Rabold EM, Laws RL, Conners EE, Gharpure R, Yin S, et al. Loss of taste and smell as distinguishing symptoms of Coronavirus disease 2019. Clin Inf Dis. 2021; 72(4):682-685.

Dong YM, Sun J, Li YX, Chen Q, Liu QQ, Sun Z, et al Development and validation of a nomogram for assessing survival in patients with Covid-19 pneumonia. Clin Inf Dis. 2021; 72(4):652-660.

McKeigue PM, Weir A, Bishop J, McGurnaghan SJ, Kennedy S, McAllister D, et al. Rapid epidemiological analysis of comorbidities and treatments as risk factors for Covid-19 in Scotland (REACT-SCOT): A population-based case-control study. Plos Med. 2020; 17(10):e1003374.

Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Roshental N. Clinical outcomes in young US adults hospitalized with Covid-19. JAMA Intern Med 2021; 181(3):379- 381.

Onder G, Rozza G, Brusaferro S. Case fatality rate and characteristics of patient dying in relation to Covid-19 in Italy. JAMA. 2020; 323(18):1775-1776.

Chen Y, Klein S, Goubaldi BT, Li H, Wu C, Osevada NM, et al. Aging in Covid-19: Vulnerability, immunity, and intervention. Ageing Research Review. 2021; 65:101205.

Gutiérrez WA, Perdomo PA. Covid-19 mortality in older people in Colombia. J Am Geriatr Soc. 2021; 69(9):2430-2432.

Cifuentes MP, Rodríguez LA, Rojas ML, Álvarez CA, Fernández JA. Socioeconomic inequalities associated with mortality for Covid-19 in Colombia: Cohort nationwide study. J Epidemiol Community Health. 2021; jech-2020-216275.

Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, el al. Lymphopenia predicts disease severity of Covid-19: A descriptive and predictive study. Signal Transduct Target Therapy. 2020; 5(1):33.

Pourbagheri-SSigaroodi A, Bashash D, Fateh F, Abolghasemi H. Laboratory findings in Covid-19 diagnosis and prognosis. Clin Chim Acta. 2020; 510:475-482.

Zeng HL, Lu QQB, Yang Q, Wang X, Yue DY, Zhang LK, et al. Longitudinal profile of laboratory parameters and their application in the prediction for fatal outcome among patients infected with SARS.CoV.2: A retrospective cohort study. Clin Inf Dis. 2021; 72(4):626-633.

Ministerio de Salud y Protección Social de Colombia. Lineamientos para la evaluación del riesgo y el tratamiento domiciliario, según la valoración médica así lo determine, en pacientes con sospecha o confirmación de infección por SARS-COV-2/Covid-19. Gestión de medicamentos y tecnología en salud GMTL01 septiembre 2020.

Schultz MJ, Gebremariam TH, Casey P, Pisani L, Sivakorn CH, Taran S et al. Pragmatic recommendations for the use of diagnostic testing and prognostic models in hospitalized patients with severe Covid-19 in low- and middle- income countries Am J Trop Med Hyg. 2021; 104(3 supp):34-47.

Wongvibulsin S, Garibaldo BT, Antar AAR, Wen J, Wang MC, Gupta A, et al. Development of score of severe Covid-19 adaptive risk predictor (SCARP), a calculator to predict severe disease or death in hospitalized patients with Covid-19. Ann Intern Med 2021; 174(6) 777-785.

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