Comportamiento temporal del consumo de antibióticos y asociación con variables climatológicas en Santiago de Cali
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Objetivo: analizar el comportamiento temporal del consumo de antibióticos y establecer su relación con aspectos climatológicos para Santiago de Cali.
Metodología: se consideró el consumo total, el de amoxicilina, azitromicina, doxiciclina, ciprofloxacina, norfloxacina, cefalexina, cefuroxima, ceftriaxona y cefepima. El consumo se estableció con las ventas de droguerías entre 2010 y 2013, y se empleó la metodología de la dosis diaria definida por 1000 habitantes-día. Se determinó el consumo mensual y anual, y se asoció con variables climatológicas del mismo periodo, por regresión lineal múltiple, seleccionando los modelos que resultaran estadísticamente significativos, validando cada uno de los supuestos.
Resultados: para el total de antibióticos el mes de más consumo durante el tiempo estudiado fue marzo de 2011, el de mayor consumo ponderado diciembre y el año de mayor consumo el 2011. El consumo total y el de cada antibiótico se asociaron con las variables climatológicas temperatura promedio, humedad relativa, lluvias, visibilidad y días con niebla.
Conclusión: se identificó un patrón de consumo para el total y para cada antibiótico que puede servir para definir intervenciones en los meses de marzo y diciembre que son los de mayor consumo.
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1. Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of respiratory viral infections. Annual Review of Virology. 2020;7:83-101.
2. Cuartas DE, Méndez F. Cambio climático y salud: retos para Colombia. Revista de la Universidad Industrial de Santander Salud. 2016;48(4):428-435.
3. Tobin EH, Thomas M, Bomar PA. Upper respiratory tract infections with focus on the common cold. StatPearls. 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532961/
4. Abi Abdallah G, Diop S, Jamme M, Legriel S, Ferré A. Respiratory infection triggering severe acute exacerbations of chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease. 2024;19:555-565.
5. Castro-Espinosa J, Molineros-Gallón LF. Consumo de antibióticos a partir de las ventas en droguerías en Santiago de Cali, Colombia. Revista Cubana de Farmacia. 2016;50(1):68-84.
6. Castro Espinosa J, Arboleda-Geovo JF, Samboni-Novoa PA. Prevalencia y determinantes de automedicación con antibióticos en una comuna de Santiago de Cali, Colombia. Revista Cubana de Farmacia. 2014;48(1):43-54.
7. Machado-Alba JE,VRLF,GMA,MDME,&FA. Patterns of Antibiotic Prescription in Colombia: Are There Differences between Capital Cities and Municipalities? Antibiotics. 2020;9(7):389.
8. Marin GH, Giangreco L, Lichtenberger P, Dorati C, Mordujovich P, Rojas-Cortés R, et al. National antimicrobial consumption in Latin America and the Caribbean: Measurements and results from 2019–2022. Antibiotics. 2025;14:240.
9. Machado-Duque ME, García DA, Emura-Vélez MH, Gaviria-Mendoza A, Giraldo-Giraldo C, Machado-Alba JE. Antibiotic prescriptions for respiratory tract viral infections in the Colombian population. Antibiotics. 2021;10:864.
10. Metlay J, Waterer G, Long A, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67.
11. Valladales-Restrepo LF, Hoyos-Guapacha MA, Hoyos-Guapacha KL, Gaviria-Mendoza A, Machado-Duque ME, Machado-Alba JE. Indicación y prescripción de macrólidos en una población colombiana. Biomedica. 2022;42:302-314.
12. Serletti L, Dutcher L, Degnan KO, Szymczak JE, Cluzet V, David MZ, et al. Analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices. Antimicrob Steward Healthc Epidemiol. 2023;3(1):e147.
13. Choe YJ, Smit MA, Mermel LA. Seasonality of respiratory viruses and bacterial pathogens. Antimicrobial Resistance & Infection Control. 2019;8(125):1-6.
14. Ryu S, Kim S, Kim BI, Klein EY, Yoon YK, Chun BC. Temporal relationship between antibiotic use and respiratory virus activities in the Republic of Korea: a time-series analysis. Antimicrobial Resistance and Infection Control. 2018:7:56.
15. Sohn HS, Oh OH, Kwon JW, Lee YS. Higher systemic antibiotic consumption in a population of South Korea (2008 – 2009). International Journal of Clinical Pharmacology and Therapeutics. 2013;51(7):585-592.
16. Wushouer H, Tian Y, Guan XD, Han S, Shi LW. Trends and patterns of antibiotic consumption in China’s tertiary hospitals: Based on a 5-year surveillance with sales records, 2011-2015. Plos One. 2017;12:e0190314.
17. Durkin MJ, Jafarzadeh SR, Hsueh K, Sallah YH, Munshi KD, Henderson RR, et al. Outpatient antibiotic prescription trends in the United States: A national cohort study. Infect Control Hosp Epidemiol. 2018;39(5):584-589.
18. Landecker H. Antibiotic resistance. Body & Society. 2016;22(4):19-52.
19. Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. Infectious Diseases. 2014;14(13):1-25.
20. Ryu S, Klein EY, Chun BC. Temporal association between antibiotic use and resistance in Klebsiella pneumoniae at a tertiary care hospital. Antimicrob Resist Infect Control. 2018:7:83.
21. Tanwar J, Das S, Fatima Z, Hameed S. Multidrug resistance: An emerging crisis. Interdiscip Perspect Infect Dis. 2014:2014:541340.
22. WHO. WHO Report on Surveillance of Antibiotic Consumption. 2016-2018 Early implementation. Geneva. 2018.
23. Frenk SM, Kit BK, Lukacs SL, Hicks LA, Gu Q. Trends in the use of prescription antibiotics: NHANES 1999–2012. J Antimicrob Chemother. 2016;71:251–256.
24. Farooqui H, Selvaraj S, Mehta A, Heymann D. Communitylevel antibiotic utilization in India and its comparison vis-à-vis European countries: Evidence from pharmaceutical sales data. Plos One. 2018;13(10):e0204805.
25. Robertson J, Iwamoto K, Hoxha I, Ghazaryan L, Abilova V, Cvijanovic A, et al. Antimicrobial medicines consumption in Eastern Europe and Central Asia-An updated cross-national study and assessment of quantitative metrics for policy action. Front. Pharmacol. 2019:9:1156.
26. Blommaert A, Marais C, Hens N, Coenen S, Muller A, Goossens H, et al. Determinants of between-country differences in ambulatory antibiotic use and antibiotic resistance in Europe: A longitudinal observational study. J Antimicrob Chemother. 2014;69:535–547.
27. Marra F, Mak S, Chong M, Patrick D. The relationship among antibiotic consumption, socioeconomic factors and climatic conditions. Can J Infect Dis Med Microbiol. 2010;21(3):e99-e106.
28. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment. Oslo. 2011.
29. Vander Stichele RH, Elseviers MM, Ferech M, Blot S, Goossens H, Group tEP. European Surveillance of Antimicrobial Consumption (ESAC): Data collection performance and methodological approach. Br J Clin Pharmacol. 2004;58(4):419-428.
30. Suda KJ, Hicks LA, Roberts RM, Hunkler RJ, Taylor TH. Trends and seasonal variation in outpatient antibiotic prescription rates in the United States, 2006 to 2010. Antimicrobial Agents and Chemotherapy. 2014;58(5):2763-2766.
31. Fleming-Dutra K, Hersh AL, Shapiro DJ, Bartoces M, Enns E, FileJr T, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA. 2016; 315q(17):1864-1873.
32. Sun L, Klein EY, Laxminarayan R. Seasonality and temporal correlation between community antibiotic use and resistance in the United States. Clinical Infectious Diseases. 2012;55(5):687–94.
33. Castro-Espinosa J, Molineros LF. Cualificación y experiencia de los vendedores de droguería para la dispensación de amoxicilina en una comuna de Santiago de Cali, Colombia. Rev Colomb Cienc Quím Farm 2018;47(1):53-70.
34. Lindgren E, Ebi KL, Johannesson M. Climate change and communicable diseases in the EU member states. Handbook for national vulnerability, impact and adaptation assessments. 2010.
35. Secretaría de Salud Pública Municipal. Grupo de Salud Pública y Epidemiologia. Boletin Epidemiologico. Santiago de Cali 2011-2012. 2013.
36. López-Lozano J, Lawes T, Nebot C, Beyaert A, Bertrand X, Hocquet D, et al. A nonlinear time-series analysis approach to identify thresholds in associations between population antibiotic use and rates of resistance. Nat Microbiol. 2019;4(7):1160-1172.
37. McGough SF, MacFadden DR, Hattab MW, Mølbak K, Santillana M. Rates of increase of antibiotic resistance and ambient temperature in Europe: A cross-national analysis of 28 countries between 2000 and 2016. Euro Surveill. 2020;25(45):1900414.
38. Hurlimann D, Limacher A, Schabel M, Zanetti G, Berger C, Muhlemann K, et al. Improvement of antibiotic prescription in outpatient care: A cluster-randomized intervention study using a sentinel surveillance network of physicians. J Antimicrob Chemother. 2015;70:602–608.
39. Van Dervelden AW, Roukens M, Van de Garde E, Lourens M. Usefulness of quality indicators for antibiotic use: Case study for the Netherlands. International Journal for Quality in Health Care. 2016;28(6):838–842.
40. Malik B, Bhattacharyya S. Antibiotic drug-resistance as a complex system driven by socioeconomic growth and antibiotic misuse. Scientific Reports. 2019;9:9788.